Retatrutide

Retatrutide

Triple-Agonist Fat Loss Peptide • GLP-1 + GIP + Glucagon Activation • Metabolic Reset • Appetite Control

Benefits of Retatrutide

 Superior Appetite Control

• Reduced cravings

• Smaller portion sizes

• Increased fullness

• Less emotional eating

 Rapid & Significant Fat Loss

• Most powerful weight-loss peptide available

• Reduces visceral fat

• Leaner waist and midsection

• Helps break plateaus

 Improved Metabolic Health

• Better glucose control

• Lower HbA1c

• Reduced insulin resistance

• Stabilised blood sugar

 Increased Energy & Fat Oxidation

• Faster metabolism

• More natural daily energy

• Improves endurance & workout recovery

 Protective Benefits

• Supports liver health (reduced fatty liver)

• Lowers cardiovascular and metabolic risk markers

• Reduces inflammation

How Retatrutide Works (Mechanisms of Action)

 1. GLP-1 Activation → Appetite Reduction

• Reduces hunger centres in the brain

• Increases satiety

• Slows gastric emptying

• Stabilises blood sugar

This results in naturally reduced calorie intake without cravings.

 2. GIP Activation → Improves Metabolism

GIP improves insulin sensitivity, stabilises glucose, and supports:

• better energy partitioning

• reduced fat storage

• improved post-meal glucose control

 3. Glucagon Activation → Fat Burning

Unlike GLP-1 and GIP alone, glucagon:

• increases basal metabolic rate

• accelerates fat oxidation

• helps maintain lean mass during weight loss

 4. Triple Pathway Synergy

The combined activation of all three receptors creates:

• faster fat loss

• more consistent appetite control

• less plateauing

• improved metabolic flexibility

• stronger improvements in HbA1c

 5. Enhances Mitochondrial Activity

Retatrutide increases metabolic output at the cellular level, supporting:

• higher energy levels

• improved exercise tolerance

• greater fat-burning efficiency

What Is Retatrutide?

Retatrutide is one of the most advanced fat-loss medications ever developed — a triple hormone agonist that activates:

• GLP-1 receptors → appetite suppression, delayed gastric emptying, improved insulin response

• GIP receptors → enhanced glucose control & metabolic flexibility

• Glucagon receptors → increased energy expenditure and fat oxidation

This makes Retatrutide significantly more powerful than semaglutide or tirzepatide.

In multiple clinical trials, Retatrutide showed the highest weight-loss outcomes of any obesity medication ever tested, with participants losing up to 24% of total body weight.

Dosage, Injection Volume & Cycling

 Concentration:

60 mg / 10 ml (6 mg/ml)

 Dose:

Starting Dose (Weeks 1–4):
2 mg weekly = 0.33 ml SC

Titration (Weeks 5–8):
4 mg weekly = 0.66 ml SC

Target Dose (Weeks 9–12+):
6 mg weekly = 1 ml SC

 Injection Volume:

• 2 mg → 0.33 ml SC

• 4 mg → 0.66 ml SC

• 6 mg → 1 ml SC

Synergy Stacks

 Metabolic Health Stack

• Retatrutide + Glutathione
  Protects liver, reduces inflammation,
  improves insulin sensitivity.

 Max Fat Loss Stack

• Retatrutide + CJC-1295 DAC + Ipamorelin
  GH support + metabolic acceleration.

 Performance & Lean Mass Protection

• Retatrutide + Epithalon
  Telomere & sleep support → improves recovery.

All treatments include a brief consultation and are supervised by qualified clinicians.

Who Is Retatrutide Ideal For?

 Individuals Struggling With Weight

• Slow metabolism

• Hormonal weight gain

• History of yo-yo dieting

 Metabolic Syndrome or Insulin Resistance

• High insulin

• Pre-diabetes

• Fatty liver

• PCOS-related weight issues

 Gym-Goers Trying to Lean Out

• Belly fat

• Stubborn fat around hips/love handles

• Bulking rebound weight

 Cycle:

12–24 weeks continuous
(longer cycles produce the best results)

 Injection Sites:

• Subcutaneous (SC) or Intramuscular (IM)

• Rotate injection sites

• Can inject near injury site

 Best Injection Time:

• Morning of a low-activity day

• With electrolytes / hydration support

 Aesthetic Fat-Loss Stack

• Retatrutide + NAD+ IM/SC
  Supports energy, reduces inflammation, accelerates fat
  oxidation.

 Safety & Side Effects

Most common:

• Nausea

• Fullness / reduced appetite

• Mild GI discomfort

• Heartburn

• Low energy during first few weeks

Less common:

• Constipation or diarrhoea

• Temporary increased sensitivity in nerves

• Headaches

Side effects reduce significantly after titration.

 Anyone Needing Strong Appetite Control

 Post-Pregnancy or Menopause Weight Gain

 Retatrutide — Scientific Research & Clinical Studies

• Phase 2 obesity trial (NEJM) – 48-week, placebo-controlled trial in adults with obesity; retatrutide produced up to ~24% body-weight reduction. New England Journal of Medicine+1
  https://www.nejm.org/doi/full/10.1056/NEJMoa2301972
  https://pubmed.ncbi.nlm.nih.gov/37366315/

• Substudy: liver fat & metabolic disease (Nat Med) – In patients with MASLD, retatrutide markedly reduced liver fat and improved metabolic markers. Nature
  https://www.nature.com/articles/s41591-024-03018-2

• Industry clinical summary – Eli Lilly’s publication summarising trial outcomes and weight-loss efficacy. Lilly Investor Relations
  https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-retatrutide-results-published-new-england-journal

(Important: still investigational; not yet broadly approved.)

 Clinical Disclaimer

This information is derived from clinical research, endocrine physiology, and metabolic science. Retatrutide at The NAD Clinic is used under a research-based wellness protocol and is not intended to diagnose, treat, or cure disease.

The Miracle Molecule