Kisspeptin-10

Kisspeptin-10

Hormonal Restoration • Fertility Support • Testosterone & LH/FSH Stimulation • HPG-Axis Activation

Benefits of Kisspeptin-10

 Hormonal Optimisation

• Increases LH and FSH

• Boosts natural testosterone

• Supports estrogen-progesterone balance

• Improves libido and sexual function

 Performance & Anti-Aging

• Restores hormonal balance after stress or dieting

• Supports recovery and energy

• Improves motivation and mood

• Can enhance training outcomes indirectly via hormonal balance

 Fertility Enhancement

• Supports ovulation

• Regulates menstrual cycles

• Improves reproductive signaling

• Increases sperm production AND quality

• Beneficial for stress-related infertility

 Psychological Benefits

• Improved mood

• Reduced anxiety around intimacy

• Enhanced emotional connection

How Kisspeptin-10 Works (Mechanisms of Action)

 1. Activates Kiss1R (GPR54) Receptors

This receptor activation stimulates the hypothalamus to release GnRH (Gonadotropin-Releasing Hormone).

 2. GnRH → LH & FSH Surge

Once GnRH is released, the pituitary produces:

• LH

• FSH

These hormones regulate reproductive and sexual function.

 3. Boosts Testosterone (Men)

LH signals Leydig cells in the testes to increase natural testosterone production.

 4. Supports Female Fertility

FSH & LH support:

• follicle development

• ovulation

• menstrual regularity

• improved estrogen/progesterone balance

 5. Restores Suppressed HPG Axes

Stress, dieting, overtraining, medications, or hormonal suppression can reduce GnRH output.
Kisspeptin re-establishes signaling at the root level of the pathway, unlike exogenous hormones.

 6. Positive Mood & Libido Effects

Kisspeptin has direct effects on limbic brain regions associated with:

• attraction

• sexual desire

• emotional bonding

• motivation

What Is Kisspeptin-10?

Kisspeptin-10 is a naturally occurring neuropeptide that plays a master regulatory role in human reproductive hormone signaling.

It stimulates the Kiss1R (GPR54) receptors in the hypothalamus, which trigger GnRH release → leading to increases in:

• LH (Luteinizing Hormone)

• FSH (Follicle-Stimulating Hormone)

• Testosterone (in males)

• Estrogen / ovulatory signaling (in females)

Kisspeptin-10 is widely used for:

• Fertility improvement

• Hormone balance restoration

• Low testosterone support

• Resetting the HPG-axis after stress, dieting, or hormonal suppression

• PCOS-related hormone dysregulation

• Enhancing libido and reproductive health

It is considered one of the safest peptides due to being part of a natural hormone cascade.

Dosage, Injection Volume & Cycling

 Concentration:

10 mg / 10 ml (1 mg/ml)

 Dose:

100–200 mcg daily
or
Every second day

 Injection Volume:

• 100 mcg → 0.1 ml SC

• 200 mcg → 0.2 ml SC

Synergy Stacks

 Hormonal Enhancement

• Kisspeptin + CJC-1295

• Kisspeptin + Ipamorelin

• Kisspeptin + NAD+ Therapy

 Fertility Support

• Kisspeptin + Glutathione

• Kisspeptin + Epithalon (telomere + egg/sperm quality)

All treatments include a brief consultation and are supervised by qualified clinicians.

Who Is Kisspeptin-10 Ideal For?

Kisspeptin-10 is excellent for:

 Men with:

• Low testosterone

• Low LH/FSH

• Poor libido

• Fertility goals (trying to conceive)

• Stress-related hypogonadism

• Post-cycle hormonal reset (natural alternative)

 Women with:

• Hormonal imbalances

• PCOS

• Ovulatory dysfunction

• Irregular cycles

• Fertility challenges

• Low libido

 Both Men & Women

• Individuals experiencing hormonal suppression from stress, dieting, extreme exercise, or chronic illness

 Cycle:

8–12 weeks
Can be repeated after a 4-week break if needed.

 Injection Sites:

• Abdomen

• Upper thigh

• Glute

• Rotating weekly

 Timings:

• Morning (for hormonal regularity)

• Night (for libido + sleep synergy)

 Men’s Health

• Kisspeptin + BPC-157 (for testicular inflammation)

• Kisspeptin + TB-500 (for vascularity + tissue repair)

 Safety & Side Effects

Kisspeptin-10 is considered extremely safe.

Possible mild effects:

• Temporary warmth

• Mild headache

• Light nausea (rare)

• Increased libido

• Slight cycle changes (females)

Avoid if:

• Pregnant or breastfeeding

• Active hormone-sensitive cancer

 Kisspeptin-10 — Scientific Research & Clinical Studies

• Central kisspeptin-10 strongly stimulates LH/FSH – Demonstrates kisspeptin-10 dose-dependently increases LH, FSH and testosterone in rats via hypothalamic–pituitary activation. PubMed
  https://pubmed.ncbi.nlm.nih.gov/15500545/

• Kisspeptin-10 stimulates gonadotropins in humans – Human study showing bolus kisspeptin-10 stimulates LH release in men and women (phase-dependent effects in women). PubMed
  https://pubmed.ncbi.nlm.nih.gov/21976724/

• Continuous infusion increases LH pulses & testosterone – In men, kisspeptin-10 infusion increases LH pulse frequency, pulse size and testosterone. PubMed
  https://pubmed.ncbi.nlm.nih.gov/21632807/

• Kisspeptin as reproductive biomarker in adolescents – Explores circulating kisspeptin and its relationship with reproductive hormones in adolescent males. PubMed
  https://pubmed.ncbi.nlm.nih.gov/36657687/

 Clinical Disclaimer

This information is based on peer-reviewed scientific research, clinical findings, and reproductive endocrinology literature. Peptide therapy at The NAD Clinic is provided for research-based wellness applications under medical supervision. Kisspeptin-10 is not intended to diagnose, treat, or cure any medical disease.

The Miracle Molecule