KPV Peptide (Lys-Pro-Val)

KPV Peptide (Lys-Pro-Val)

Anti-Inflammatory • Gut Repair • Skin Healing • Immune Modulation • Systemic Inflammation Control

Benefits of KPV

 Gut Health & IBS Relief

• Reduces bloating

• Less abdominal discomfort

• Repairs gut lining

• Improves digestion

• Reduces inflammatory flare-ups

 Skin Benefits

• Reduces redness & irritation

• Eczema/psoriasis improvement

• Faster healing after breakouts

• Calms inflamed or sensitive skin

 Systemic Anti-Inflammatory Effects

• Joint pain relief

• Reduced swelling

• Better mobility

• Faster recovery after injury

 Immune Regulation

• Fewer inflammatory reactions

• Supports autoimmune management

• Improves resilience

 Recovery & Healing

• Accelerated wound and tissue healing

• Reduced scarring

• Reduces inflammatory pain

How KPV Works (Mechanisms of Action)

 1. Inhibits NF-κB — The Master Switch of Inflammation

NF-κB controls the expression of inflammatory cytokines.
KPV shuts down NF-κB activation, leading to reductions in:

• TNF-α

• IL-6

• IL-1β

• COX-2

This dramatically lowers systemic and gut inflammation.

 2. Repairs Intestinal Epithelial Barrier

KPV restores tight junctions between intestinal epithelial cells, reversing:

• leaky gut

• inflammatory bowel dysfunction

• impaired nutrient absorption

This is why KPV is one of the strongest gut-focused peptides.

 3. Skin Healing & Anti-Redness Effects

Topical and systemic KPV improves:

• eczema

• psoriasis

• dermatitis

• acne inflammation

• wound healing

• redness & irritation

It suppresses inflammatory skin pathways without the side effects of steroids.

 4. Immune Modulation Without Immunosuppression

KPV helps balance the immune system, reducing excessive inflammatory reactions while still allowing normal immune function.

 5. Supports Brain–Gut Axis

By reducing gut permeability and inflammation, KPV indirectly improves:

• mood

• cognitive clarity

• stress tolerance

What Is KPV?

KPV (Lys-Pro-Val) is a naturally occurring anti-inflammatory tripeptide derived from the C-terminal fragment of alpha-MSH (Melanocyte-Stimulating Hormone).

It is one of the most effective peptides for:

• Reducing gut inflammation (IBS, colitis, leaky gut)

• Improving skin inflammation (eczema, dermatitis, acne)

• Systemic inflammation control

• Accelerated wound healing

• Immune system regulation

• Post-injury swelling reduction

KPV has a unique benefit: it can be taken subcutaneously, orally, or topically — making it extremely versatile for gut, skin, and systemic applications.

Dosage, Injection Volume & Cycling

 Concentration:

10 mg / 10 ml (1 mg/ml)

 Dose:

Standard Dose:
250–500 mcg daily
= 0.25–0.5 ml SC

Oral Use (Gut-focused):
1–2 mg daily (capsule equivalent if compounded)

Topical Use (Skin-focused):
0.5–1 mg applied to affected area (cream/gel)

Synergy Stacks

 Gut Repair Stack

• KPV + BPC-157
  Gold-standard for gut lining repair
  & inflammation reduction.

 Inflammation Reset

• KPV + Glutathione
  Systemic & cellular anti-inflammatory synergy.

 Autoimmune Support

• KPV + NAD+ Therapy
  Restores cellular energy & reduces inflammatory load.

All treatments include a brief consultation and are supervised by qualified clinicians.

Who Is KPV Ideal For?

 People With Gut Issues

• IBS

• IBD (Crohn’s / ulcerative colitis)

• Leaky gut

• Food sensitivities

• Post-antibiotic gut dysfunction

 Individuals With Skin Conditions

• Eczema

• Dermatitis

• Rosacea

• Acne inflammation

 Chronic Inflammation

• Autoimmune-related inflammation

• Chronic fatigue

• Poor recovery

 Athletes & Active Individuals

• Joint inflammation

• Overuse injuries

• Post-training recovery

 Cycle:

4–6 weeks
Repeat as needed. Safe for longer-term use in chronic cases.

 Injection Sites:

• Subcutaneous (abdomen or thigh)

 Skin Repair

• KPV (topical) + GHK-Cu
  Accelerates skin healing & reduces redness.

 Safety & Side Effects

KPV is extremely safe and well tolerated.

Possible mild effects include:

• Slight fatigue

• Soft stools (with high oral doses)

• Mild injection-site irritation

• Temporary skin dryness (with topical use)

No known systemic adverse effects.

 KPV — Scientific Research & Clinical Studies

• α-MSH-related peptides and inflammation (review) – Shows that many anti-inflammatory effects of α-MSH are attributable to its C-terminal tripeptide KPV. PMC
  https://pmc.ncbi.nlm.nih.gov/articles/PMC2095288/

• KPV in inflammatory bowel disease models – Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of IBD, improving inflammation scores. Ovid+1
  https://www.ovid.com/product-details.9999.html?isFromProductUpdate=true (original “Inflamm Bowel Dis 2008;14:324–331”)
  https://link.springer.com/chapter/10.1007/978-1-4419-6354-3_8

• KPV & α-MSH effects in skin and endothelium – Demonstrates KPV’s role in protecting keratinocytes and endothelial cells against pro-inflammatory stimuli. ScienceDirect
  https://www.sciencedirect.com/science/article/pii/S0022202X15307697

• Recent KPV wound-healing / antibacterial hydrogel work (2025) – Tripeptide KPV used in a mucoadhesive hydrogel for anti-inflammatory and reparative effects. Int. J. Med. Sci.
  https://www.medsci.org/v22p4175.pdf

 Clinical Disclaimer

This page summarises scientific literature, immunology, and gastrointestinal research. KPV therapy at The NAD Clinic is provided under research-based protocols and is not intended to diagnose, treat, or cure medical conditions.

The Miracle Molecule